Employing one-molecule optical and AFM imaging and force-spectroscopy tactics, we seek to unravel the mechanistic facets of the framework and dynamics of chromosomes. Our research interests include things like:

This concern is for screening whether or not you are a human customer and to circumvent automatic spam submissions.

The following articles are merged in Scholar. Their put together citations are counted just for the initial post.

Our get the job done was swiftly followed up by Some others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their conclusions on transistors created from single- and multi-walled carbon nanotubes in Utilized Physics Letters.

2015, discovery that condensin is a very adaptable protein structure; and very first detection of DNA knots applying nanopores

Microbiology has only been around to get a century, since we began to review micro-organisms a lot more critically. I assumed nanobiology was an proper expression, simply because all molecular Organic related interactions occur on the nanoscale: a protein is a few nanometres in sizing, DNA is two nm thick.’

Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigation from DNA supercoiling research of nucleosomes and DNA repair service proteins to DNA translocation by means of nanopores. Recently his investigation has centered on learning mobile division with bacteria on chip, even though his ultimate curiosity is during the path of noticing synthetic cells.

Learning DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.

‘You shouldn't just take into consideration the issues of tomorrow, but also take into account the thoughts in the working day just after tomorrow’

There was one dilemma although — we didn't observe any measurable electrical conduction from The only polymer molecules. We concluded that at The one-molecule degree, conducting polymers ended up really not these types of fantastic conductors, which was somewhat disappointing. We Therefore broadened our view to try to search out much more promising molecules.

[fourteen] In 2005 Dekker turned involved with Netherlands-extensive discussions about Intelligent Style, a motion that he has considering the fact that Evidently distanced himself from. Dekker advocates that science and faith will not be in opposition but could be harmonized.

2001, discovery of one-electron transistors at space temperature based upon nanotubes; realization of very first logic circuits with carbon nanotube equipment; and discovery in the molecular composition of DNA fix enzymes with AFM

2005, discovery with the system of cees dekker DNA uncoiling by topoisomerase enzymes; discovery of very long-vary conformational changes in Mre11/DNA repair complexes; and first force measurements on a DNA molecule in a nanopore

Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in gray, the rim of your pore is highlighted in red, along with a 3D rendering in the movement with the DNA rod is exhibited.