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It was only while in the 1990s while, when nanotechnology had State-of-the-art to some stage where solitary molecules could be manipulated, that the primary experimental equipment began to seem.

Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I

Given that 2000, Dekker has shifted the leading concentrate of his operate to biophysics where he reports the Attributes of one biomolecules and cells using the resources of nanotechnology. This modification of field was pushed by his fascination for that outstanding functioning of Organic molecular structures, along with with the extensive-time period perspective that lots of appealing discoveries can be predicted During this industry.[5] Recent strains of research in his biophysics group are within the areas of:[6]

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine from the dynamics DNA supercoils and the invention of supercoil hopping

Immediate immobilization of indigenous yeast iso-1 cytochrome c on bare gold: fast electron relay to redox enzymes and zeptomole protein-film voltammetry

Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division https://www.ceesdekker.net with micro organism on chip, although his ultimate fascination is inside the direction of noticing artificial cells.

2000, discovery that nanotubes can carry amazing large existing densities; solved the controversial issue of electronic transportation as a result of DNA molecules by measurements of insulating conduct at The one molecule level; and demonstration of an AFM approach for one-molecule manipulation of nanotubes

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‘The fantastically delicate way by which elements in mother nature operate in no way ceases to amaze me. If we resolve the puzzle of how life arrived into currently being, I anticipate that my amazement at the complexity of generation can have elevated and with it my awe with the greatness with the Creator.’

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Cees Dekker is Distinguished College Professor at TU Delft. Experienced for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes from the nineteen nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His existing analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker can be an elected member of the KNAW and fellow to the APS and the IOP.

2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid

2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes